In 2017, Ethan Winters is drawn to a derelict plantation in Dulvey, Louisiana, by a message from his wife, Mia, who has been presumed dead for three years. He finds Mia imprisoned in the basement of a seemingly abandoned house, but she becomes violent and attacks him, forcing him to kill her. After receiving a call from a woman named Zoe offering assistance, Ethan is attacked by a revived Mia, who cuts his hand off. Jack, the patriarch of the Baker family, captures Ethan. After Zoe reattaches his hand, Ethan is held captive by Jack, his wife Marguerite, their son Lucas, and an elderly, catatonic, wheelchair-bound woman. Ethan escapes but is pursued around the house by Jack, who has powerful regenerative abilities. In the basement, Ethan discovers reanimated monsters known as Molded. Zoe reveals that she is Jack's daughter, and that the family and Mia are infected with a virus, but can be cured with a special serum. Ethan makes his way to an old house to retrieve the serum ingredients, kills Marguerite, and has visions of a young girl. Lucas captures Zoe and Mia and forces Ethan to navigate a booby-trapped barn to find them. Ethan chases away Lucas and frees Zoe and Mia. Zoe develops two serum doses, but they are attacked by Jack, now heavily mutated; Ethan kills him using one of the serums.